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你正在浏览Islets期刊下所有文献
  • CXCL10- a path to β-cell death.

    abstract：:The ability of the β-cells to control blood glucose levels depends on their function and mass. In both, type 1 and type 2 diabetes mellitus the main processes leading to β-cell failure are apoptosis and loss of function. Many studies demonstrate how cytokines and chemokines have an active role in triggering the immune...

    journal_title：Islets

    pub_type： 杂志文章

    doi：10.4161/isl.1.3.9110

    authors： Paroni F,Domsgen E,Maedler K

    更新日期：2009-11-01 00:00:00

  • Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration.

    abstract：:The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3, Neurog3) is critical for the development of the endocrine cells of the islets. Either disrupted or forced expression of Ngn3 early in mouse pancreas development abrogates the formation of islets. The successive waves of Ngn3 expression that occur duri...

    journal_title：Islets

    pub_type： 杂志文章,评审

    doi：10.4161/isl.1.3.9877

    authors： Rukstalis JM,Habener JF

    更新日期：2009-11-01 00:00:00

  • Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice.

    abstract：:Zinc transporter 8 (ZnT8) has been identified as a β-cell-specific Zinc transporter expressed in insulin-secretory granules. Recent genome wide association studies indicated that Arg325Trp polymorphism of Slc30a8 encoding ZnT8 is associated with susceptibility to type 2 diabetes. As a first step towards understanding ...

    journal_title：Islets

    pub_type： 杂志文章

    doi：10.4161/isl.1.2.9433

    authors： Tamaki M,Fujitani Y,Uchida T,Hirose T,Kawamori R,Watada H

    更新日期：2009-09-01 00:00:00

  • Effect of upregulation of NeuroD in insulin-producing liver cells.

    abstract：:NeuroD (BETA2), a bHLH transcription factor is known to be involved in early pancreatic endocrine as well as neuronal differentiation. NeuroD is known to regulate distinct sets of molecules that are important for survival and differentiation of pancreatic cells. We assessed whether forced expression of NeuroD, can ind...

    journal_title：Islets

    pub_type： 杂志文章

    doi：10.4161/isl.1.1.8993

    authors： Appavoo M,Tuch B

    更新日期：2009-07-01 00:00:00

  • Factors affecting islet graft embolization in the liver of diabetic mice.

    abstract：:BACKGROUND: Embolic occlusion of the portal vein due to islet transplantation is one of the major reasons for reduced survival of transplanted islets. In this study, we examined the location of islets as well as the correlation between islet and portal vein size after intraportal islet transplantation and evaluated li...

    journal_title：Islets

    pub_type： 杂志文章

    doi：

    authors： Sakata N,Obenaus A,Chan N,Mace J,Chinnock R,Hathout E

    更新日期：2009-07-01 00:00:00

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